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BDBM186060 US9163011, 14

SMILES: COCC#Cc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(N)c1

InChI Key: InChIKey=OWNJETMTIIFDJG-LJQANCHMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186060   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta amyloid A4 protein


(Homo sapiens (Human))
BDBM186060
PNG
(US9163011, 14)
Show SMILES COCC#Cc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(N)c1
Show InChI InChI=1S/C20H19F3N6O3/c1-19(20(22,23)10-32-18(25)29-19)16-12(21)5-6-14(27-16)28-17(30)15-13(24)8-11(9-26-15)4-3-7-31-2/h5-6,8-9H,7,10,24H2,1-2H3,(H2,25,29)(H,27,28,30)/t19-/m1/s1
PDB
MMDB

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Similars

US Patent
n/an/a 540n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...


US Patent US9163011 (2015)


BindingDB Entry DOI: 10.7270/Q2Z60MV1
More data for this
Ligand-Target Pair