BDBM18631 (18Z)-18-[(3-cyclohexanecarbonylthiophen-2-yl)methylidene]-12-methoxy-3,5,5-trimethyl-17-oxa-6-azatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2(7),3,8,11,13,15-heptaen-13-ol::Ketone, 17

SMILES COc1c(O)ccc2OC(=Cc3sccc3C(=O)C3CCCCC3)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=SUULNAGREGMRMF-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18631   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18631((18Z)-18-[(3-cyclohexanecarbonylthiophen-2-yl)meth...)
Affinity DataIC50:  1nM EC50:  0.400nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed