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BDBM187164 US9670181, 44 4-((2-(benzylamino)-6-methoxyquinolin-3-yl)methyl)-1-ethyl-6,7-dimethoxyisoquinolin-3-ol

SMILES: CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCc2ccccc2)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=BBKDYBIZGOPNJK-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187164   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187164
PNG
(US9670181, 44 4-((2-(benzylamino)-6-methoxyquinoli...)
Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCc2ccccc2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C31H31N3O4/c1-5-26-24-17-29(38-4)28(37-3)16-23(24)25(31(35)34-26)15-21-13-20-14-22(36-2)11-12-27(20)33-30(21)32-18-19-9-7-6-8-10-19/h6-14,16-17H,5,15,18H2,1-4H3,(H,32,33)(H,34,35)
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PC cid
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US Patent
n/an/a 8n/an/an/an/a7.425



Allergan Inc

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair