BDBM18780 6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine::CHEMBL281412::P18

SMILES CCc1nc(N)nc(N)c1-c1ccc(OC)cc1

InChI Key InChIKey=SRYOSRABCMAHOE-UHFFFAOYSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18780   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of the wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering And Biotechnology At Thailand

LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  1.01nM ΔG°:  -12.3kcal/mole IC50:  350nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  1.30nMAssay Description:Inhibition constant against Plasmodium falciparum dihydrofolate reductaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering And Biotechnology At Thailand

LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  37.8nM IC50: >5.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  39nMAssay Description:Inhibition of the S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  86nMAssay Description:Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataIC50: >2.50E+4nMAssay Description:Antiplasmodial activity (IC50) against Plasmodium falciparum Clone with mutant enzyme C59R+S108N- pfDihydrofolate reductase (K1CB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Sickkids

Curated by ChEMBL
LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed