BDBM1885 3-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea::CHEMBL317356::N-(2-Phenethyl)-N -(2-(5-bromopyridyl))thiourea::PETT Analog 52::cid_2429552

SMILES Brc1ccc(NC(=S)NCCc2ccccc2)nc1

InChI Key InChIKey=FKDHVFZSRUETTG-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 1885   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM1885(3-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea ...)
Affinity DataIC50:  15nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM1885(3-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea ...)
Affinity DataIC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Factor XIa (0.23 ug/mL) was incubated with Boc-Glu-Ala-Arg-AMC substrate (15 uM) in 10 uL of assay buffer for 2 hr at room temperature. Read fluoresc...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beactica

Curated by ChEMBL
LigandPNGBDBM1885(3-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea ...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM1885(3-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea ...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beactica

Curated by ChEMBL
LigandPNGBDBM1885(3-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea ...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptase by surface plasmon resonance based biosensor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM1885(3-(5-bromopyridin-2-yl)-1-(2-phenylethyl)thiourea ...)
Affinity DataIC50:  5.00E+4nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Scott L. Diamond, University of Pennsy...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay