BDBM191345 US9670203, Compound 2.8

SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cc(F)c(F)cc5F)[C@@H]4c3c2)ccn1

InChI Key InChIKey=FPGVPWSNALFMJP-ACRUOGEOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 191345   

LigandPNGBDBM191345(US9670203, Compound 2.8)
Affinity DataIC50:  3.00E+3nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM191345(US9670203, Compound 2.8)
Affinity DataIC50:  1.30E+4nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent