BDBM191600 2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl)isonicotinic acid (N19)::US10173996, Example 89::US9604961, Example 89::US9714230, 89::US9908865, Example 89

SMILES Cc1cc(Cl)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O

InChI Key InChIKey=PSOBPHXKKHPWMU-UHFFFAOYSA-N

Data  30 IC50  2 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 191600   

TargetLysine-specific demethylase 5A [1-739](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  5.00E+3nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length human KDM5B expressed in baculovirus expression system using (ARTK(me3)QTARKSTGGKAPRKQLA peptide substMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5C [1-789](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  1.70E+4nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5D [1-760](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  1.10E+4nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-588](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataKd:  60nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B [1-604](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataKd:  70nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  240nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  175nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  800nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged KDM4C (2 to 372 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged KDM2B (1 to 650 residues) expressed in baculovirus infected sf9 cells using biotin-H3K36me2 su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM5A in human ZR-75-1 cells assessed as reduction in H3K4me3 demethylation incubated for 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM5B in human ZR-75-1 cells assessed as reduction in H3K4me3 demethylation incubated for 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3 su...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: <100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A/5B(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataEC50:  90nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  630nMAssay Description:Inhibition of KDM2B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of KDM3A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  99nMAssay Description:Inhibition of KDM4A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  160nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  820nMAssay Description:Inhibition of KDM2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of KDM6B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  35nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4B(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of KDM4B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4D(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  110nMAssay Description:Inhibition of KDM4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of KDM5A (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B [1-755](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  1.00E+3nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed