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BDBM192920 US10526329, Compound 134::US9670204, 134 1-(3-(4-(2-ethyl-3-((4-(4-fluorophenyl)thiazol-2-yl)(methyl)amino)imidazo[1,2-a]pyridin-6-yl)piperidin-1-yl)azetidin-1-yl)ethanone

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC1)C1CN(C1)C(C)=O

InChI Key: InChIKey=PCDNBXRGGMPGNR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 192920   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM192920
PNG
(US10526329, Compound 134 | US9670204, 134 1-(3-(4-...)
Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC1)C1CN(C1)C(C)=O
Show InChI InChI=1S/C29H33FN6OS/c1-4-25-28(33(3)29-32-26(18-38-29)21-5-8-23(30)9-6-21)36-15-22(7-10-27(36)31-25)20-11-13-34(14-12-20)24-16-35(17-24)19(2)37/h5-10,15,18,20,24H,4,11-14,16-17H2,1-3H3
PDB

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KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/a8.525



Galapagos NV

US Patent


Assay Description
Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...


US Patent US9670204 (2017)


BindingDB Entry DOI: 10.7270/Q2W66HZS
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM192920
PNG
(US10526329, Compound 134 | US9670204, 134 1-(3-(4-...)
Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC1)C1CN(C1)C(C)=O
Show InChI InChI=1S/C29H33FN6OS/c1-4-25-28(33(3)29-32-26(18-38-29)21-5-8-23(30)9-6-21)36-15-22(7-10-27(36)31-25)20-11-13-34(14-12-20)24-16-35(17-24)19(2)37/h5-10,15,18,20,24H,4,11-14,16-17H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



GALAPAGOS NV

US Patent




US Patent US10526329 (2020)


BindingDB Entry DOI: 10.7270/Q2Z60RGR
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM192920
PNG
(US10526329, Compound 134 | US9670204, 134 1-(3-(4-...)
Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC1)C1CN(C1)C(C)=O
Show InChI InChI=1S/C29H33FN6OS/c1-4-25-28(33(3)29-32-26(18-38-29)21-5-8-23(30)9-6-21)36-15-22(7-10-27(36)31-25)20-11-13-34(14-12-20)24-16-35(17-24)19(2)37/h5-10,15,18,20,24H,4,11-14,16-17H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...


US Patent US10526329 (2020)


BindingDB Entry DOI: 10.7270/Q2Z60RGR
More data for this
Ligand-Target Pair