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BDBM195395 US9670212, 54 3-amino-N-({2-[4-(1H-imidazol-1-ylacetyl)-1,4-diazepan-1-yl]-8-methylquinolin-3-yl}methyl)pyrazine-2-carboxamide

SMILES: Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(CC1)C(=O)Cn1ccnc1

InChI Key: InChIKey=FILURIMAKXPPIF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 195395   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM195395
PNG
(US9670212, 54 3-amino-N-({2-[4-(1H-imidazol-1-ylac...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(CC1)C(=O)Cn1ccnc1
Show InChI InChI=1S/C26H29N9O2/c1-18-4-2-5-19-14-20(15-31-26(37)23-24(27)30-7-6-29-23)25(32-22(18)19)35-10-3-9-34(12-13-35)21(36)16-33-11-8-28-17-33/h2,4-8,11,14,17H,3,9-10,12-13,15-16H2,1H3,(H2,27,30)(H,31,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



Exelixis Inc

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


US Patent US9670212 (2017)


BindingDB Entry DOI: 10.7270/Q27H1GR0
More data for this
Ligand-Target Pair