BDBM199363 US9221831, 28
SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1CNCc1ccccc1)OC
InChI Key InChIKey=PGANIOBIXBHMAK-BUVWRSTLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 199363
Affinity DataKi: 0.0400nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Affinity DataKi: 9.01nM ΔG°: -11.9kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for t-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane...More data for this Ligand-Target Pair
Affinity DataKi: 147nM ΔG°: -10.1kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...More data for this Ligand-Target Pair
Affinity DataKi: 494nM ΔG°: -8.60kcal/molepH: 7.4 T: 2°CAssay Description:Delta-opioid Receptor Binding Assay Procedures were conducted as
follows. Radioligand dose-displacement assays used 0.3 nM
[3H]-Naltrindole (Perkin...More data for this Ligand-Target Pair
Affinity DataEC50: 1.22E+3nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...More data for this Ligand-Target Pair
Affinity DataEC50: 50.4nMpH: 7.4 T: 2°CAssay Description:[35S]GTPgammaS functional assays were conducted using freshly thawed u-receptor membranes (Perkin Elmer, Shelton, Conn.). Assay reactions
were prepa...More data for this Ligand-Target Pair
Affinity DataEC50: 8.42nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. κ
opioid receptor membrane solution was prepared by sequentially adding
final ...More data for this Ligand-Target Pair
Affinity DataEC50: 526nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows.
Delta opioid receptor membrane solution was prepared by sequentially
adding fin...More data for this Ligand-Target Pair