BDBM202371 US10081606, Compound I-3::US9238629, I-3::US9765038, Compound I-3

SMILES COc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1

InChI Key InChIKey=ARWJHMPQGVRJGR-UHFFFAOYSA-N

Data  6 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 202371   

TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataEC50:  55nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-745,751-967](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataEC50:  55nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataIC50:  20nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataIC50: <1nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataEC50: >1.00E+3nMAssay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataIC50:  20nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataIC50: <1nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataIC50:  20nMAssay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-249,301-1210,T790M,L858R](Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataIC50: <1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202371(US10081606, Compound I-3 | US9238629, I-3 | US9765...)
Affinity DataEC50: >1.00E+3nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent