BDBM205126 2-{[(3r,6r)-1-{[5-fluoro-2- (1,3-thiazol-2-yl)pyridin-3- yl]carbonyl}-6- methylpiperidin-3-yl]oxy}-3- methylpyridine-4-carbonitrile::US9546152, example 35

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cc(F)cnc1-c1nccs1)Oc1nccc(C#N)c1C

InChI Key InChIKey=VEEQAPLZSRNWFQ-CXAGYDPISA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 205126   

TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205126(2-{[(3r,6r)-1-{[5-fluoro-2- (1,3-thiazol-2-yl)pyri...)
Affinity DataKi:  0.300nMAssay Description:Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205126(2-{[(3r,6r)-1-{[5-fluoro-2- (1,3-thiazol-2-yl)pyri...)
Affinity DataKi:  160nMAssay Description:Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205126(2-{[(3r,6r)-1-{[5-fluoro-2- (1,3-thiazol-2-yl)pyri...)
Affinity DataIC50:  13nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205126(2-{[(3r,6r)-1-{[5-fluoro-2- (1,3-thiazol-2-yl)pyri...)
Affinity DataIC50:  453nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent