BDBM205479 PDD00017273 (4)::US20230278998, Compound PDD00017273

SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)s3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1

InChI Key InChIKey=IFWUBRBMMNTBRZ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 205479   

TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataIC50:  26nMpH: 7.4Assay Description:Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataIC50: <100nMAssay Description:PARG in vitro assays were conducted in standard 384-well plates in a total volume of 15 μL. 5 μL of PARG (389-976) (manufactured by Chempar...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataEC50:  37nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataEC50:  26nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed