BDBM20557 AMG 517::CHEMBL229430::JMC503515 Compound 23::N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide::US8796328, A::US8802711, H
SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
InChI Key InChIKey=YUTIXVXZQIQWGY-UHFFFAOYSA-N
Data 21 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 20557
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.900nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.620nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.760nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2]i) using the Fluorescence...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of low pH-induced calcium influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.5nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.5nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.760nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilizationMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilizationMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute Of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen
Amgen
Affinity DataIC50: 0.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair