BDBM20657 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[1,2-a][1,2,4]triazine-6-carboxamide::pyrrolo[2,1-f][1,2,4]triazine analogue, 11j

SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)N[C@@H](C)c4ccccc4)c(C)c23)c1

InChI Key InChIKey=STNJCYKOXYBBIA-KRWDZBQOSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 20657   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20657(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50:  2.20nM EC50:  10nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20657(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20657(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 minsMore data for this Ligand-Target Pair