BDBM207565 US10501467, Example 10::US9260440, 10::US9617273, Example 10

SMILES Fc1cc2[nH]c3CC(Cc4n[nH]c(=O)c(c1)c2c34)c1ccccc1

InChI Key InChIKey=JRJUVAGIZBYGNU-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 207565   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207565(US10501467, Example 10 | US9260440, 10 | US9617273...)
Affinity DataIC50:  5.80nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207565(US10501467, Example 10 | US9260440, 10 | US9617273...)
Affinity DataIC50:  5.80E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207565(US10501467, Example 10 | US9260440, 10 | US9617273...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207565(US10501467, Example 10 | US9260440, 10 | US9617273...)
Affinity DataEC50:  12nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM207565(US10501467, Example 10 | US9260440, 10 | US9617273...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207565(US10501467, Example 10 | US9260440, 10 | US9617273...)
Affinity DataIC50:  5.80E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent