BDBM207906 US9546153, ex. 42
SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CC1
InChI Key InChIKey=SHENXRCDBJGWNU-GOSISDBHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 207906
Affinity DataIC50: 2.70nMpH: 7.2 T: 2°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Mus musculus)
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of IRAK4 in mouse whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair