BDBM209475 US10328074, Example III-16::US11077107, Example III-16::US9266891, III-16

SMILES CNc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C

InChI Key InChIKey=DCXAWDGRFZGDMY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 209475   

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209475(US10328074, Example III-16 | US11077107, Example I...)
Affinity DataIC50:  5nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-168](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM209475(US10328074, Example III-16 | US11077107, Example I...)
Affinity DataIC50:  5nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209475(US10328074, Example III-16 | US11077107, Example I...)
Affinity DataIC50:  5nMAssay Description:This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent