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BDBM209727 US9273033, 25

SMILES: Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(F)c(=O)n(C)c1

InChI Key: InChIKey=KJEJRNWTBMWUOA-CVEARBPZSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 209727   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM209727
PNG
(US9273033, 25)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(F)c(=O)n(C)c1
Show InChI InChI=1S/C21H21FN4O2/c1-12-4-5-19(24-8-12)16-6-15(16)11-28-20-17(9-23-13(2)25-20)14-7-18(22)21(27)26(3)10-14/h4-5,7-10,15-16H,6,11H2,1-3H3/t15-,16+/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
1.55 -12.0n/an/an/an/an/an/a25



Merck Sharp & Dohme Corp

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


US Patent US9273033 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W2R
More data for this
Ligand-Target Pair