BDBM21016 CHEMBL22870::L 732138::L-732,138::L732138::N-acetyltryptophan 3,5-bis(trifluoromethyl)benzyl ester::[3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-indol-3-yl)propanoate
SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
InChI Key InChIKey=BYYQYXVAWXAYQC-IBGZPJMESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 35 hits for monomerid = 21016
Affinity DataKi: 0.730nM ΔG°: -12.5kcal/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P frome human NK1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 130nM ΔG°: -9.39kcal/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 134nMAssay Description:Displacement of [3H]substance P frome rat NK2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 134nMAssay Description:Displacement of [3H]substance P frome rat NK2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 134nM ΔG°: -9.37kcal/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
Affinity DataKi: 134nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 134nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.92E+5nMAssay Description:The inhibitory concentration of the compound against rat neurokinin-1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 3.24nMAssay Description:Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.More data for this Ligand-Target Pair
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Affinity to NK3 receptors assayed by displacement of [125I]-Bolton-Hunter labeled eledoisin radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]substance P frome human NK1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Binding affinity to the NK2 receptor assayed by displacement of [125I]-Neurokinin AMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.More data for this Ligand-Target Pair