BDBM212622 BDBM212747::US9278954, 1.13::US9278954, 1.26

SMILES CC(C(=O)NC1CC1C)c1ccc(O[C@@H]2CCN(C2)c2ncnc(OCC(C)(C)O)c2Cl)cc1

InChI Key InChIKey=HPFRHOLVXNWLMP-VYJHHOQDSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 212622   

TargetAcetyl-CoA carboxylase 2 [129-967](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM212622(BDBM212747 | US9278954, 1.13 | US9278954, 1.26)
Affinity DataIC50:  233nMpH: 7.5Assay Description:Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [129-967](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM212622(BDBM212747 | US9278954, 1.13 | US9278954, 1.26)
Affinity DataIC50:  325nMpH: 7.5Assay Description:Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [129-967](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM212622(BDBM212747 | US9278954, 1.13 | US9278954, 1.26)
Affinity DataIC50:  681nMpH: 7.5Assay Description:Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [129-967](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM212622(BDBM212747 | US9278954, 1.13 | US9278954, 1.26)
Affinity DataIC50:  127nMpH: 7.5Assay Description:Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [129-967](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM212622(BDBM212747 | US9278954, 1.13 | US9278954, 1.26)
Affinity DataIC50:  121nMpH: 7.5Assay Description:Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent