BDBM21422 4-Alkyl-4-methoxypiperidine derivative, 8n::N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-{4-methoxy-4-[(4-phenylphenyl)methyl]piperidin-1-yl}benzamide

SMILES COC1(Cc2ccc(cc2)-c2ccccc2)CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN(C)C)CSc2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=OFNZVEACOGKFQD-DIPNUNPCSA-N

Data  2 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 21422   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21422(4-Alkyl-4-methoxypiperidine derivative, 8n | N-[(4...)
Affinity DataKi:  0.900nM ΔG°:  -12.3kcal/mole IC50:  160nM EC50:  600nMpH: 7.4 T: 2°CAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21422(4-Alkyl-4-methoxypiperidine derivative, 8n | N-[(4...)
Affinity DataKi: <1nM EC50:  1.10E+3nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21422(4-Alkyl-4-methoxypiperidine derivative, 8n | N-[(4...)
Affinity DataEC50:  600nMAssay Description:Inhibition of Bcl-XLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed