BDBM21434 N-Benylpiperazine derivative, 23j::N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-(4-{[2-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)benzamide

SMILES CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2C(F)(F)F)CC1

InChI Key InChIKey=UHIJFHPHVXEEAI-GDLZYMKVSA-N

Data  5 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 21434   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21434(N-Benylpiperazine derivative, 23j | N-[(4-{[(2R)-4...)
Affinity DataKi: <0.5nM IC50:  85nM EC50:  390nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21434(N-Benylpiperazine derivative, 23j | N-[(4-{[(2R)-4...)
Affinity DataKi: <1nM EC50:  130nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21434(N-Benylpiperazine derivative, 23j | N-[(4-{[(2R)-4...)
Affinity DataKi:  3.5nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 2(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM21434(N-Benylpiperazine derivative, 23j | N-[(4-{[(2R)-4...)
Affinity DataKi:  49nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM21434(N-Benylpiperazine derivative, 23j | N-[(4-{[(2R)-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged mouse wild type MCL1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21434(N-Benylpiperazine derivative, 23j | N-[(4-{[(2R)-4...)
Affinity DataEC50:  390nMAssay Description:Inhibition of Bcl-XLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed