BDBM214690 US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

SMILES Cc1cc(Nc2nc(nc3ccccc23)[C@H](O)c2ccc(F)cc2)n[nH]1

InChI Key InChIKey=DCRWIATZWHLIPN-QGZVFWFLSA-N

Data  8 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 214690   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataKd:  1.50E+4nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataKd:  500nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataKd:  2.10E+4nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataKd:  8.80E+3nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:.(R)- and (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was tested in a radioligand binding assay, according to th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataKd:  28.5nMpH: 7.4 T: 2°CAssay Description:.(R)- and (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was tested in a radioligand binding assay, according to th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50:  1.48E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2B6(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50: >4.00E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50:  2.69E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50:  1.52E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50:  1.18E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50: >4.00E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214690(US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataIC50:  1.70E+3nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent