BindingDB logo
myBDB logout

BDBM220211 8-(3-methylphenyl)-6- pyrrolidin-l-yl-7-[4- (trifluoromethyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 6.23

SMILES: Cc1cccc(c1)-c1nc2nc(nc(N3CCCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key: InChIKey=QRYZKTAEJHPCGA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 220211   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p53-binding protein Mdm2


(Homo sapiens (Human))
BDBM220211
PNG
(8-(3-methylphenyl)-6- pyrrolidin-l-yl-7-[4- (trifl...)
Show SMILES Cc1cccc(c1)-c1nc2nc(nc(N3CCCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C25H22F3N5O2/c1-15-5-4-6-17(13-15)22-30-20-19(23(32-11-2-3-12-32)31-21(29-20)24(34)35)33(22)14-16-7-9-18(10-8-16)25(26,27)28/h4-10,13H,2-3,11-12,14H2,1H3,(H,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.27E+3n/an/an/an/an/a25



Merck Sharp & Dohme Corp

US Patent


Assay Description
An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...


US Patent US9540377 (2017)


BindingDB Entry DOI: 10.7270/Q2RF5X1F
More data for this
Ligand-Target Pair