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BDBM220865 6-[methyl(2- methylpropyl)amino]- 8-(3-methylphenyl)-7- [4- (trifluoromethyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 6.71

SMILES: CC(C)CN(C)c1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O

InChI Key: InChIKey=KECLNRNMCLERBN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 220865   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p53-binding protein Mdm2


(Homo sapiens (Human))
BDBM220865
PNG
(6-[methyl(2- methylpropyl)amino]- 8-(3-methylpheny...)
Show SMILES CC(C)CN(C)c1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O
Show InChI InChI=1S/C26H26F3N5O2/c1-15(2)13-33(4)24-20-21(30-22(32-24)25(35)36)31-23(18-7-5-6-16(3)12-18)34(20)14-17-8-10-19(11-9-17)26(27,28)29/h5-12,15H,13-14H2,1-4H3,(H,35,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 940n/an/an/an/an/a25



Merck Sharp & Dohme Corp

US Patent


Assay Description
An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...


US Patent US9540377 (2017)


BindingDB Entry DOI: 10.7270/Q2RF5X1F
More data for this
Ligand-Target Pair