BDBM2213 2-Pyridinone derivative 8::3-[2-(1,3-benzothiazol-2-yl)ethyl]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::CHEMBL95426::Pyridinone deriv. 5

SMILES CCc1cc(CCc2nc3ccccc3s2)c(=O)[nH]c1C

InChI Key InChIKey=LZQXQNZBXMSGAI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2213   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM2213(2-Pyridinone derivative 8 | 3-[2-(1,3-benzothiazol...)
Affinity DataIC50:  370nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Merck Reserch Laboratories

Curated by ChEMBL
LigandPNGBDBM2213(2-Pyridinone derivative 8 | 3-[2-(1,3-benzothiazol...)
Affinity DataIC50:  370nMAssay Description:Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM2213(2-Pyridinone derivative 8 | 3-[2-(1,3-benzothiazol...)
Affinity DataIC50:  370nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed