BDBM22160 pyrazole compound, 14a::sodium 5-({5-[(1E,3S,5R)-6-carboxy-3,5-dihydroxyhex-1-en-1-yl]-4-(4-fluorophenyl)-6-(1-methylethyl)pyrimidin-2-yl}amino)-1-methyl-1H-pyrazole-3-carboxylate::sodium 5-({5-[(1E,3S,5R)-6-carboxy-3,5-dihydroxyhex-1-en-1-yl]-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl}amino)-1-methyl-1H-pyrazole-3-carboxylate

SMILES CC(C)c1nc(Nc2cc(nn2C)C(O)=O)nc(-c2ccc(F)cc2)c1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O

InChI Key InChIKey=FHALQUHVYPUUQM-PIIXRYACSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22160   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

LigandPNGBDBM22160(pyrazole compound, 14a | sodium 5-({5-[(1E,3S,5R)-...)
Affinity DataIC50:  0.900nM EC50:  13.7nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed