BDBM221713 US10568884, Cpd 34::US9314464, 34::US9593100, Compound 34::USRE49556, Compound 34

SMILES CCCS(=O)(=O)Nc1c(F)ccc(-c2nn(cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C(C)C)c1F

InChI Key InChIKey=GTVBBDKLBUVTKF-HNNXBMFYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 221713   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM221713(US10568884, Cpd 34 | US9314464, 34 | US9593100, Co...)
Affinity DataIC50:  2.70nMpH: 7.5 T: 2°CAssay Description:B-Raf (V600E; 4 μM) and biotinylated Mek (kinase dead; 10 nM) were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM221713(US10568884, Cpd 34 | US9314464, 34 | US9593100, Co...)
Affinity DataIC50:  2.70nMAssay Description:B-Raf (V600E; 4 pM) and biotinylated Mek (kinase dead; 10 nM) were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM221713(US10568884, Cpd 34 | US9314464, 34 | US9593100, Co...)
Affinity DataIC50:  2.70nMAssay Description:B-Raf (V600E; 4 pM) and biotinylated Mek (kinase dead; 10 nM) were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM221713(US10568884, Cpd 34 | US9314464, 34 | US9593100, Co...)
Affinity DataIC50:  2.70nMAssay Description:The B-Raf kinase activity reaction was started by the addition of 10 μl piper well of 2×ATP (10 μM) diluted in assay buffer. After 3 hours,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM221713(US10568884, Cpd 34 | US9314464, 34 | US9593100, Co...)
Affinity DataIC50:  2.70nMAssay Description:B-Raf (V600E; 4 pM) and biotinylated Mek (kinase dead; 10 nM) were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent