BDBM22396 (1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophenyl)-1,3-thiazol-2-yl]-8-methyl-8-azabicyclo[3.2.1]octane::WIN 35,065-2::WIN35,065-2::Win 35,065::methyl (1R,2S,3S,5S)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate::troparil, 1R-(exo,exo)-isomer

SMILES COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1c1ccccc1)N2C

InChI Key InChIKey=OMBOXYLBBHNWHL-YJNKXOJESA-N

Data  9 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 22396   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  54nMAssay Description:Binding affinity for [3H]DA (Dopamine transporter) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  89nMAssay Description:Binding affinity of compound on dopamine transporters of rat striated membranes using [3H]- mazindol.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  135nMAssay Description:Binding affinity on dopamine and serotonin transporters in striated membranes using [3H]- paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  186nMAssay Description:Binding affinity for Serotonin transporter was determined by [3H]5-HT (serotonin) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNorepinephrine transporter(RAT)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  920nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTransporter(Rattus norvegicus (rat))
Research Triangle Institute

LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  920nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  1.90E+3nM ΔG°:  -7.80kcal/molepH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  1.96E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataIC50:  204nMAssay Description:Inhibitory activity against Serotonin transporter was determined for [3H]5-HT (serotonin) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataIC50:  163nMAssay Description:Inhibitory activity on dopamine transporters of rat striated membranes using [3H]- mazindol.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataIC50:  58nMAssay Description:Inhibitory activity determined for [3H]DA (Dopamine transporter) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataIC50:  23nMpH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataIC50:  2.71E+3nMAssay Description:Inhibitory activity on dopamine and serotonin transporters in striated membranes using [3H]- paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed