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BDBM224899 US9321756, 152

SMILES: N[C@H]1CCCCN1c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1

InChI Key: InChIKey=CFASKVKPGHACTK-AGDOHHJYNA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224899   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224899
PNG
(US9321756, 152)
Show SMILES N[C@H]1CCCCN1c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1/C20H21N7S/c21-17-5-1-2-9-27(17)18-6-3-4-16(24-18)14-11-23-15-8-7-12(10-13(14)15)19-25-26-20(22)28-19/h3-4,6-8,10-11,17,23H,1-2,5,9,21H2,(H2,22,26)/t17-/s2
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.307n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM224899
PNG
(US9321756, 152)
Show SMILES N[C@H]1CCCCN1c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1/C20H21N7S/c21-17-5-1-2-9-27(17)18-6-3-4-16(24-18)14-11-23-15-8-7-12(10-13(14)15)19-25-26-20(22)28-19/h3-4,6-8,10-11,17,23H,1-2,5,9,21H2,(H2,22,26)/t17-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224899
PNG
(US9321756, 152)
Show SMILES N[C@H]1CCCCN1c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1/C20H21N7S/c21-17-5-1-2-9-27(17)18-6-3-4-16(24-18)14-11-23-15-8-7-12(10-13(14)15)19-25-26-20(22)28-19/h3-4,6-8,10-11,17,23H,1-2,5,9,21H2,(H2,22,26)/t17-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.79n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair