BDBM22566 5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole::CHEMBL129198::JNJ 7777120
SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
InChI Key InChIKey=HUQJRYMLJBBEDO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 94 hits for monomerid = 22566
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Binding affinity of compound towards rat histamine H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 2.60nM ΔG°: -11.7kcal/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 2.70nM ΔG°: -11.7kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 2.70nM ΔG°: -11.7kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 3.89nMAssay Description:Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Antagonist activity at Homo sapiens (human) histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nM ΔG°: -11.4kcal/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
Affinity DataKi: 4.17nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 4.27nMAssay Description:Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.5nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.60nM ΔG°: -11.4kcal/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 4.70nM ΔG°: -11.4kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsMore data for this Ligand-Target Pair
Affinity DataKi: 6.31nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Antagonist activity at human histamine H4 receptor by functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.8kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.8kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.8kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
Affinity DataKi: 15.8nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsMore data for this Ligand-Target Pair
Affinity DataKi: 18.6nMAssay Description:Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillat...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Binding affinity to histamine 4 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co...More data for this Ligand-Target Pair