BindingDB logo
myBDB logout

BDBM226886 US9328096, 579

SMILES: Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccon2)c(Cl)cc1Cl

InChI Key: InChIKey=LZBDDZMLORLMGY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226886   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226886
PNG
(US9328096, 579)
Show SMILES Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccon2)c(Cl)cc1Cl
Show InChI InChI=1S/C26H17Cl2FN6O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(36)32-23-13-22(26(37)31-14-15-8-10-38-34-15)33-35(23)16-5-2-1-3-6-16/h1-13H,14H2,(H,31,37)(H,32,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.15n/an/an/an/an/a37



Pfizer Inc

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226886
PNG
(US9328096, 579)
Show SMILES Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccon2)c(Cl)cc1Cl
Show InChI InChI=1S/C26H17Cl2FN6O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(36)32-23-13-22(26(37)31-14-15-8-10-38-34-15)33-35(23)16-5-2-1-3-6-16/h1-13H,14H2,(H,31,37)(H,32,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.15n/an/an/an/an/a37



Pfizer Inc

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair