BDBM227696 2-{1-[6-(5-chloropyridin- 3-yl)-7-[(trans-4- methylcyclohexyl)methyl]- 2-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)-7h- purin-8-yl]-1- methoxyethyl}benzonitrile (enantiomer 1)::US9540377, 23.111::US9540377, 23.112
SMILES COC(C)(c1nc2nc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1)c1ccccc1C#N
InChI Key
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 227696
Affinity DataIC50: 2.77nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Affinity DataIC50: 0.435nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair