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BDBM227737 US9540377, 6.82

SMILES: CN(CC(C)(C)C)c1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O

InChI Key: InChIKey=AJOXNQWBGDSJDL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227737   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p53-binding protein Mdm2


(Homo sapiens (Human))
BDBM227737
PNG
(US9540377, 6.82)
Show SMILES CN(CC(C)(C)C)c1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O
Show InChI InChI=1S/C27H28F3N5O2/c1-16-7-6-8-18(13-16)23-32-21-20(35(23)14-17-9-11-19(12-10-17)27(28,29)30)24(33-22(31-21)25(36)37)34(5)15-26(2,3)4/h6-13H,14-15H2,1-5H3,(H,36,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 899n/an/an/an/an/a25



Merck Sharp & Dohme Corp

US Patent


Assay Description
An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...


US Patent US9540377 (2017)


BindingDB Entry DOI: 10.7270/Q2RF5X1F
More data for this
Ligand-Target Pair