BDBM22812 5-fluoro-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 32

SMILES Fc1ccc2NC(=O)C(=O)c2c1

InChI Key InChIKey=GKODDAXOSGGARJ-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 22812   

TargetCoagulation factor XII(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22812(5-fluoro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Show SMILES Fc1ccc2NC(=O)C(=O)c2c1
Show InChI InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22812(5-fluoro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Show SMILES Fc1ccc2NC(=O)C(=O)c2c1
Show InChI InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22812(5-fluoro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Show SMILES Fc1ccc2NC(=O)C(=O)c2c1
Show InChI InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22812(5-fluoro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Show SMILES Fc1ccc2NC(=O)C(=O)c2c1
Show InChI InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
St. Jude Research Hospital

LigandPNGBDBM22812(5-fluoro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Show SMILES Fc1ccc2NC(=O)C(=O)c2c1
Show InChI InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair