BDBM228179 2-(3-Ethyl-[1,2,4]triazol-1-yl)-1-{(R)-2-methyl-4-[2-trifluoromethyl-4-(2-trifluoromethyl-pyrimidin-5-yl)-thiazol-5-yl]-piperazin-1-yl}-ethanone::US10047080, 6

SMILES CCc1ncn(CC(=O)N2C(C)CNCC2c2sc(cc2-c2cnc(nc2)C(F)(F)F)C(F)(F)F)n1

InChI Key InChIKey=MVXSYVSOVOTJHN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 228179   

TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM228179(2-(3-Ethyl-[1,2,4]triazol-1-yl)-1-{(R)-2-methyl-4-...)
Affinity DataIC50:  148nMAssay Description:Stock solutions of test compounds are made up at a concentration of 10 mM in DMSO, and serially diluted in PBS containing 0.5% BSA to concentrations ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM228179(2-(3-Ethyl-[1,2,4]triazol-1-yl)-1-{(R)-2-methyl-4-...)
Affinity DataIC50:  2nMpH: 7.4Assay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent