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BDBM228683 US9346810, 144

SMILES: CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)-c1ccncc1

InChI Key: InChIKey=YZBSSBJGUNRJQS-KRWDZBQOSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 228683   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM228683
PNG
(US9346810, 144)
Show SMILES CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)-c1ccncc1
Show InChI InChI=1S/C21H21N7/c1-27(19-3-2-16(12-24-19)15-4-8-22-9-5-15)17-7-11-28(13-17)21-18-6-10-23-20(18)25-14-26-21/h2-6,8-10,12,14,17H,7,11,13H2,1H3,(H,23,25,26)/t17-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0550n/an/an/an/an/a25



Hutchison MediPharma Limited

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair