BDBM22956 4-(methylsulfanyl)phenyl 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate::CHEMBL96057::Indomethacin derivative, 9

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)Oc3ccc(SC)cc3)c2c1

InChI Key InChIKey=LEZAXGVGAFLQRL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22956   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine

LigandPNGBDBM22956(4-(methylsulfanyl)phenyl 2-{1-[(4-chlorophenyl)car...)
Affinity DataIC50:  2.60E+3nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22956(4-(methylsulfanyl)phenyl 2-{1-[(4-chlorophenyl)car...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine

LigandPNGBDBM22956(4-(methylsulfanyl)phenyl 2-{1-[(4-chlorophenyl)car...)
Affinity DataIC50:  3.00E+3nMAssay Description:In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22956(4-(methylsulfanyl)phenyl 2-{1-[(4-chlorophenyl)car...)
Affinity DataIC50:  300nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed