BDBM23269 (2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide::Cinnamic hydroxamate deriv., 13::US10188756, Compound CN87::US11505523, Compound PCI34051

SMILES COc1ccc(\C=C\C(=O)NO)cc1

InChI Key InChIKey=BQDLTSGIXOYYHY-QPJJXVBHSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 23269   

TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  7.90E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  55.7nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  833nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  238nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >1.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  23.2nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 7(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  2.57E+3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  7.5nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 11(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: >20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50:  301nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent