BDBM239026 US10028934, Compound 40::US10478423, Cpd. 40::US9408850, 40::US9597317, 40

SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1

InChI Key InChIKey=IIFDFWIYQQQBGS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 239026   

TargetReceptor-type tyrosine-protein kinase FLT3 [564-993](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50: <50nMpH: 7.9 T: 2°CAssay Description:The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit [544-976](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50:  88nMpH: 7.9Assay Description:The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50: <50nMpH: 7.9Assay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50:  88nMAssay Description:i. Enzyme—The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50: <50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50:  88nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50: <50nMAssay Description:i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Affinity DataIC50:  88nMpH: 7.9Assay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent