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BDBM239635 US9394309, 88

SMILES: Cc1ccc(NC(=O)c2cc(F)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1

InChI Key: InChIKey=XFKFEXOXXXDLME-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 239635   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239635
PNG
(US9394309, 88)
Show SMILES Cc1ccc(NC(=O)c2cc(F)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17F6N5OS/c1-15-4-5-19(32-24(36)17-9-18(25)11-20(10-17)37(26,27,28,29)30)12-22(15)34-7-8-35-23(34)13-21(33-35)16-3-2-6-31-14-16/h2-14H,1H3,(H,32,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 41n/an/an/an/a9.64



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


US Patent US9394309 (2016)


BindingDB Entry DOI: 10.7270/Q2C53JRC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239635
PNG
(US9394309, 88)
Show SMILES Cc1ccc(NC(=O)c2cc(F)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17F6N5OS/c1-15-4-5-19(32-24(36)17-9-18(25)11-20(10-17)37(26,27,28,29)30)12-22(15)34-7-8-35-23(34)13-21(33-35)16-3-2-6-31-14-16/h2-14H,1H3,(H,32,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/a7.022



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


US Patent US9394309 (2016)


BindingDB Entry DOI: 10.7270/Q2C53JRC
More data for this
Ligand-Target Pair