BDBM240644 US9409924, (3aR,5R,6R,7S,7aR)-2-(ethylamino)-7-fluoro-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazol-6-ol

SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2F)S1

InChI Key InChIKey=ICJGJSLPQBWFGV-OZRXBMAMSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 240644   

TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM240644(US9409924, (3aR,5R,6R,7S,7aR)-2-(ethylamino)-7-flu...)
Affinity DataKi:  0.400nM ΔG°:  -12.8kcal/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM240644(US9409924, (3aR,5R,6R,7S,7aR)-2-(ethylamino)-7-flu...)
Affinity DataEC50:  13nMAssay Description:Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent