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BDBM243343 US10053454, Example 87::US10196387, Example 87

SMILES: Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3ccc(cc3c2c1)C(=O)N1CCOCC1)S(=O)(=O)C1CC1

InChI Key: InChIKey=DUMHGBPQNUATHI-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 243343   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM243343
PNG
(US10053454, Example 87 | US10196387, Example 87)
Show SMILES Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3ccc(cc3c2c1)C(=O)N1CCOCC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C26H26N4O6S/c1-14-23(15(2)36-28-14)17-12-20-19-11-16(26(32)29-7-9-35-10-8-29)3-6-22(19)30(37(33,34)18-4-5-18)24(20)21(13-17)25(27)31/h3,6,11-13,18H,4-5,7-10H2,1-2H3,(H2,27,31)
PDB

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UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...


US Patent US10053454 (2018)


BindingDB Entry DOI: 10.7270/Q2C24ZFN
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM243343
PNG
(US10053454, Example 87 | US10196387, Example 87)
Show SMILES Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3ccc(cc3c2c1)C(=O)N1CCOCC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C26H26N4O6S/c1-14-23(15(2)36-28-14)17-12-20-19-11-16(26(32)29-7-9-35-10-8-29)3-6-22(19)30(37(33,34)18-4-5-18)24(20)21(13-17)25(27)31/h3,6,11-13,18H,4-5,7-10H2,1-2H3,(H2,27,31)
PDB

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UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...


US Patent US10196387 (2019)


BindingDB Entry DOI: 10.7270/Q29S1T30
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM243343
PNG
(US10053454, Example 87 | US10196387, Example 87)
Show SMILES Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3ccc(cc3c2c1)C(=O)N1CCOCC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C26H26N4O6S/c1-14-23(15(2)36-28-14)17-12-20-19-11-16(26(32)29-7-9-35-10-8-29)3-6-22(19)30(37(33,34)18-4-5-18)24(20)21(13-17)25(27)31/h3,6,11-13,18H,4-5,7-10H2,1-2H3,(H2,27,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...


US Patent US10196387 (2019)


BindingDB Entry DOI: 10.7270/Q26112DD
More data for this
Ligand-Target Pair