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BDBM243347 4-{5-[3-Morpholin-4- ylmethy1-5-(4- trifluoromethyl-pyrimidin- 2-ylamino)-phenyl]- oxazol-2-yl}-4,7-diaza- spiro[2.5]octan-8-one::US10053455, 003

SMILES: FC(F)(F)c1ccnc(Nc2cc(CN3CCOCC3)cc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1

InChI Key: InChIKey=XMAXUMVOUHBAHS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243347   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM243347
PNG
(4-{5-[3-Morpholin-4- ylmethy1-5-(4- trifluoromethy...)
Show SMILES FC(F)(F)c1ccnc(Nc2cc(CN3CCOCC3)cc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1
Show InChI InChI=1S/C25H26F3N7O3/c26-25(27,28)20-1-4-30-22(33-20)32-18-12-16(15-34-7-9-37-10-8-34)11-17(13-18)19-14-31-23(38-19)35-6-5-29-21(36)24(35)2-3-24/h1,4,11-14H,2-3,5-10,15H2,(H,29,36)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/a7.825



AB SCIENCE

US Patent


Assay Description
SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...


US Patent US10053455 (2018)


BindingDB Entry DOI: 10.7270/Q27946PV
More data for this
Ligand-Target Pair