BDBM244034 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-ethyl-6-methoxy-4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidine-2,4-diamine::US10053458, 92

SMILES CCN1Cc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)cc2C(C)(C)C1

InChI Key InChIKey=IHDNVTSTSSSUJW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 244034   

TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM244034(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-et...)
Affinity DataIC50: <10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM244034(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-et...)
Affinity DataIC50: <10nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent