BDBM244100 US9546173, cmpd 82::US9546173, cmpd 83::n-((s)-2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((1-methyl-2-oxopiperidin-4-yl)amino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide

SMILES CN1CCC(CC1=O)Nc1ncc2c(CN(C(=O)N[C@H](CO)c3ccccc3)C2(C)C)n1

InChI Key InChIKey=KQPGCRIUCIHOLP-LRTDYKAYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 244100   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM244100(US9546173, cmpd 82 | US9546173, cmpd 83 | n-((s)-2...)
Affinity DataIC50:  1.16E+3nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM244100(US9546173, cmpd 82 | US9546173, cmpd 83 | n-((s)-2...)
Affinity DataIC50:  208nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent