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BDBM244262 US9550763, Compound I-010

SMILES: CCOC(=O)c1cnc(Oc2ccc(Nc3cc(=O)n(CC)c(=O)n3Cc3ccc(Cl)cc3)cc2)s1

InChI Key: InChIKey=PQXOZSYPZIESDL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 244262   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 3


(Homo sapiens (Human))
BDBM244262
PNG
(US9550763, Compound I-010)
Show SMILES CCOC(=O)c1cnc(Oc2ccc(Nc3cc(=O)n(CC)c(=O)n3Cc3ccc(Cl)cc3)cc2)s1
Show InChI InChI=1S/C25H23ClN4O5S/c1-3-29-22(31)13-21(30(25(29)33)15-16-5-7-17(26)8-6-16)28-18-9-11-19(12-10-18)35-24-27-14-20(36-24)23(32)34-4-2/h5-14,28H,3-4,15H2,1-2H3
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a7.5n/a



Shionogi & Co., Ltd

US Patent


Assay Description
Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...


US Patent US9550763 (2017)


BindingDB Entry DOI: 10.7270/Q2V126TQ
More data for this
Ligand-Target Pair