BDBM24461 N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-5-methyl-1-(2-methylpropyl)-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide::Substituted Pyrazolone, 3

SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1

InChI Key InChIKey=AROMUEFGOQGFHF-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 24461   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24461(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  7.90nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24461(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  8nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24461(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  915nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM24461(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  999nM ΔG°:  -8.10kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM24461(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24461(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataIC50:  205nMAssay Description:Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24461(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed