BDBM244829 US9422293, 39 and 39A::US9738649, Example 39A

SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)cc1

InChI Key InChIKey=MRHHSXHMRZMNIM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 244829   

TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  6nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  9.5nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  18nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  23nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  6nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  18nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  9.5nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244829(US9422293, 39 and 39A | US9738649, Example 39A)
Affinity DataIC50:  23nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent